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Neurodevelopmental outcome at 2 years of age after general anaesthesia and awake-regional anaesthesia in infancy (GAS): an international multicentre, randomised controlled trial

Abstract:

Preclinical data suggest that general anaesthetics affect brain development. There is mixed evidence from cohort studies that young children exposed to anaesthesia can have an increased risk of poor neurodevelopmental outcome. We aimed to establish whether general anaesthesia in infancy has any effect on neurodevelopmental outcome. Here we report the secondary outcome of neurodevelopmental outcome at 2 years of age in the General Anaesthesia compared to Spinal anaesthesia (GAS) trial.In this ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/S0140-6736(15)00608-X

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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
NPEU
Role:
Author
Publisher:
Elsevier
Journal:
Lancet (London, England) More from this journal
Volume:
387
Issue:
10015
Pages:
239-250
Publication date:
2016-01-01
DOI:
ISSN:
0140-6736
Pmid:
26507180
Language:
English
Keywords:
Pubs id:
pubs:586472
UUID:
uuid:5f0b7175-353c-44cf-97c9-eaadb373b244
Local pid:
pubs:586472
Source identifiers:
586472
Deposit date:
2017-02-13

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