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Thiopurine methyltransferase genotype-phenotype discordance and thiopurine active metabolite formation in childhood acute lymphoblastic leukaemia.

Abstract:

AIMS: In children with acute lymphoblastic leukaemia (ALL) bone marrow activity can influence red blood cell (RBC) kinetics, the surrogate tissue for thiopurine methyltransferase (TPMT) measurements. The aim of this study was to investigate TPMT phenotype-genotype concordance in ALL, and the influence of TPMT on thiopurine metabolite formation. METHODS: We measured TPMT (activity, as units ml(-1) packed RBCs and genotype) at diagnosis (n = 1150) and TPMT and thioguanine nucleotide (TGN) and m...

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Publication status:
Published

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Publisher copy:
10.1111/bcp.12066

Authors


Lennard, L More by this author
Cartwright, CS More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Trial Service Unit
Richards, SM More by this author
Journal:
British journal of clinical pharmacology
Volume:
76
Issue:
1
Pages:
125-136
Publication date:
2013-07-05
DOI:
EISSN:
1365-2125
ISSN:
0306-5251
URN:
uuid:5f06dbb3-6c1b-41ac-a91d-1686f5a35444
Source identifiers:
416535
Local pid:
pubs:416535

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