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Dynamics of human adipose lipid turnover in health and metabolic disease.

Abstract:

Adipose tissue mass is determined by the storage and removal of triglycerides in adipocytes. Little is known, however, about adipose lipid turnover in humans in health and pathology. To study this in vivo, here we determined lipid age by measuring (14)C derived from above ground nuclear bomb tests in adipocyte lipids. We report that during the average ten-year lifespan of human adipocytes, triglycerides are renewed six times. Lipid age is independent of adipocyte size, is very stable across a...

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Publication status:
Published

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Publisher copy:
10.1038/nature10426

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Journal:
Nature
Volume:
478
Issue:
7367
Pages:
110-113
Publication date:
2011-10-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:5f0251aa-c07c-4197-97b7-4fd1765bc8d0
Source identifiers:
192853
Local pid:
pubs:192853

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