Membranous structures transfer cell surface proteins across NK cell immune synapses.

Journal article

Intercellular transfer of cell surface proteins is widespread and facilitates several recently discovered means for immune cell communication. Here, we examined the molecular mechanism for intercellular exchange of the natural killer (NK) cell receptor KIR2DL1 and HLA-C, prototypical proteins that swap between NK cells and target cells. Transfer was contact dependent and enhanced for cells expressing cognate receptor/ligand pairs but did not depend on KIR2DL1 signaling. To a lesser extent, pr...

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Authors: Williams, G; Collinson, L; Brzostek, J; Eissmann, P; Almeida, C

• Publication status: Published
• Journal: Traffic (Copenhagen, Denmark)
• Volume: 8
• Issue: 9
• Pages: 1190-1204
• Publication date: 2007-09-01
• DOI: 10.1111/j.1600-0854.2007.00603.x
• EISSN: 1600-0854
• ISSN: 1398-9219
• Language: English
• Keywords: Cell Surface Extensions; Humans; Intercellular Junctions; Microscopy, Electron; Antibodies, Monoclonal; Organic Chemicals; Protein Binding; Cell Line; Transfection; Cell Communication; Cell Line, Tumor; Killer Cells, Natural; Pyrimidines; Protein Transport; HLA-C Antigens; src-Family Kinases; Coated Pits, Cell-Membrane; Acids; Cell Membrane; Receptors, KIR2DL1; Membrane Proteins