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The somatostatin-secreting pancreatic δ-cell in health and disease

Abstract:

The somatostatin-secreting δ-cells comprise ~5% of the cells of the pancreatic islets. The δ-cells have complex morphology and might interact with many more islet cells than suggested by their low numbers. δ-Cells contain ATP-sensitive potassium channels, which open at low levels of glucose but close when glucose is elevated. This closure initiates membrane depolarization and electrical activity and increased somatostatin secretion. Factors released by neighbouring α-cells or β-cells amplify ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1038/s41574-018-0020-6

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; OCDEM
Oxford college:
Harris Manchester College
Huising, MO More by this author
Knut and Alice Wallenberg Foundation More from this funder
Swedish Research Council More from this funder
Hartwell Foundation for Biomedical Research More from this funder
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Reviews Endocrinology Journal website
Volume:
14
Issue:
6
Pages:
404–414
Publication date:
2018-05-17
DOI:
EISSN:
1759-5037
ISSN:
1759-5029
Pubs id:
pubs:853649
URN:
uri:5ef4526a-aa0e-4e7e-a131-a875cc8ef50a
UUID:
uuid:5ef4526a-aa0e-4e7e-a131-a875cc8ef50a
Local pid:
pubs:853649
Language:
English
Keywords:

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