Journal article
Ligand induced activation of human TRPM2 requires the terminal ribose of ADPR and involves Arg 1433 and Tyr 1349
- Abstract:
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TRPM2 is a Ca2+-permeable non-selective cation channel activated by binding of adenosine 5ʹ-diphosphoribose (ADPR) to its cytoplasmic NUDT9H domain. Activation of TRPM2 by ADPR downstream of oxidative stress has been implicated in the pathogenesis of a number of human diseases rendering TRPM2 an attractive novel target for pharmacological intervention. However, the structural basis underlying this activation is largely unknown. Since ADP alone did not activate or antagonize the channel, we us...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.3MB, Terms of use)
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- Publisher copy:
- 10.1042/BCJ20170091
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Bibliographic Details
- Publisher:
- Portland Press
- Journal:
- Biochemical Journal More from this journal
- Volume:
- 474
- Issue:
- 13
- Pages:
- 2159-2175
- Publication date:
- 2017-05-17
- Acceptance date:
- 2017-05-15
- DOI:
- EISSN:
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1470-8728
- ISSN:
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0264-6021
Item Description
- Keywords:
- Pubs id:
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pubs:695951
- UUID:
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uuid:5eed8820-4189-436c-812b-c806a5ffefb2
- Local pid:
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pubs:695951
- Source identifiers:
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695951
- Deposit date:
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2017-05-19
Terms of use
- Copyright holder:
- Fliegert et al
- Copyright date:
- 2017
- Notes:
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Copyright
© 2017 The Authors.
This is an Accepted Manuscript; not the final Version of Record. You are encouraged to use the final Version of Record that, when published, will replace this manuscript and be freely available under a Creative Commons licence.
- Licence:
- CC Attribution (CC BY)
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