Journal article icon

Journal article

Cadherin2/4-signaling via PTP1B and catenins is critical for nucleokinesis during radial neuronal migration in the neocortex

Abstract:

Cadherins are critical for the radial migration of excitatory projection neurons into the developing neocortical wall. However, the specific cadherins and the signaling pathways that regulate radial migration are not well understood. Here we show that cadherin 2 (CDH2) and CDH4 cooperate to regulate radial migration via the protein tyrosine phosphatase 1B (PTP1B) and α- and β-catenins. Surprisingly, perturbation of cadherin-mediated signaling does not affect the formation and extension of lea...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1242/dev.132456

Authors


Martinez-Garay, I More by this author
Gil-Sanz, C More by this author
Franco, SJ More by this author
Espinosa, A More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Expand authors...
More from this funder
Funding agency for:
Gil-Sanz, C
Expand funders...
Publisher:
Company of Biologists Publisher's website
Journal:
Development Journal website
Volume:
143
Issue:
12
Pages:
2121-2134
Publication date:
2016-06-06
DOI:
EISSN:
1477-9129
ISSN:
0950-1991
URN:
uuid:5eec6acc-e294-4cb0-b121-bd5d15451cf2
Source identifiers:
622956
Local pid:
pubs:622956

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP