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Journal article

ISL-1 is induced in stomach mesenchyme in the presence of pancreatic epithelia.

Abstract:

BACKGROUND/PURPOSE: beta-Cell replacement offers a potential cure for type 1 diabetes mellitus in children. We have previously shown that stomach mesenchyme (SM) is competent to derive islet tissue by mesenchymal-to-epithelial transition (iMET). The aim of this study was to further characterize the developmental fate of this SM in the presence of pancreatic epithelia (PE) in SM/PE recombinants. The homeobox ISL-1 was examined in these recombinants because this gene is restricted to the dorsa...

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Publication status:
Published

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Authors


Rowan-Hull, AM More by this author
Robertson, SA More by this author
Johnson, PR More by this author
Journal:
Journal of pediatric surgery
Volume:
44
Issue:
2
Pages:
348-352
Publication date:
2009-02-05
DOI:
EISSN:
1531-5037
ISSN:
0022-3468
URN:
uuid:5eeb1a7d-8179-44fe-a1df-cd9a9f633dae
Source identifiers:
244902
Local pid:
pubs:244902

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