- Abstract:
-
Elevated production of the matrix glycosaminoglycan hyaluronan is strongly implicated in epithelial tumor progression. Inhibition of synthesis of the hyaluronan precursor UDP-glucuronic acid (UDP-GlcUA) therefore presents an emerging target for cancer therapy. Human UDP-glucose 6-dehydrogenase (hUGDH) catalyzes, in two NAD(+)-dependent steps without release of intermediate aldehyde, the biosynthetic oxidation of UDP-glucose (UDP-Glc) to UDP-GlcUA. Here, we present a structural characterizatio...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1074/jbc.m111.234682
-
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- Journal:
- The Journal of biological chemistry
- Volume:
- 286
- Issue:
- 27
- Pages:
- 23877-23887
- Publication date:
- 2011-07-05
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- URN:
-
uuid:5eea68bb-c750-4ead-9a81-cdf86ea1c253
- Source identifiers:
-
134958
- Local pid:
- pubs:134958
- Copyright date:
- 2011
Journal article
Structure and mechanism of human UDP-glucose 6-dehydrogenase.
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