Journal article icon

Journal article

Structure and mechanism of human UDP-glucose 6-dehydrogenase.

Abstract:

Elevated production of the matrix glycosaminoglycan hyaluronan is strongly implicated in epithelial tumor progression. Inhibition of synthesis of the hyaluronan precursor UDP-glucuronic acid (UDP-GlcUA) therefore presents an emerging target for cancer therapy. Human UDP-glucose 6-dehydrogenase (hUGDH) catalyzes, in two NAD(+)-dependent steps without release of intermediate aldehyde, the biosynthetic oxidation of UDP-glucose (UDP-Glc) to UDP-GlcUA. Here, we present a structural characterizatio...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1074/jbc.m111.234682

Authors


Journal:
The Journal of biological chemistry
Volume:
286
Issue:
27
Pages:
23877-23887
Publication date:
2011-07-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:5eea68bb-c750-4ead-9a81-cdf86ea1c253
Source identifiers:
134958
Local pid:
pubs:134958

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP