- Abstract:
-
A paucity of novel acting antibacterials is in development to treat the rising threat of antimicrobial resistance, particularly in Gram-negative hospital pathogens, which has led to renewed efforts in antibiotic drug discovery. Fluoroquinolones are broad-spectrum antibacterials that target DNA gyrase by stabilizing DNA-cleavage complexes, but their clinical utility has been compromised by resistance. We have identified a class of antibacterial thiophenes that target DNA gyrase with a unique m...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Publisher copy:
- 10.1073/pnas.1700721114
-
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- Grant:
- Joint Undertaking under Grant Agreement 115583
- Publisher:
- National Academy of Sciences Publisher's website
- Journal:
- Proceedings of the National Academy of Sciences Journal website
- Volume:
- 114
- Issue:
- 22
- Pages:
- E4492-E4500
- Publication date:
- 2017-05-15
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- Pubs id:
-
pubs:695746
- URN:
-
uri:5ee9c29d-63e1-41c8-b496-d45d1f4900ef
- UUID:
-
uuid:5ee9c29d-63e1-41c8-b496-d45d1f4900ef
- Local pid:
- pubs:695746
- Language:
- English
- Keywords:
- Copyright holder:
- Chan et al.
- Copyright date:
- 2017
Journal article
Thiophene antibacterials that allosterically stabilize DNA-cleavage complexes with DNA gyrase
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