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The CALM1 core promoter polymorphism is not associated with hip osteoarthritis in a United Kingdom Caucasian population.

Abstract:

OBJECTIVE: A convincing genetic association with hip osteoarthritis (OA) of a functional single nucleotide polymorphism (SNP) in the core promoter of the calmodulin 1 gene CALM1 was recently reported in a Japanese population. The T-allele of the SNP encoded OA susceptibility and this was mediated by a reduced expression of CALM1. Our objective was to assess whether the SNP was also associated with hip OA in UK Caucasians. METHODS: The SNP was genotyped in 920 cases that had undergone elective...

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Publication status:
Published

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Publisher copy:
10.1016/j.joca.2005.11.001

Authors


Loughlin, J More by this author
Sinsheimer, JS More by this author
Chapman, K More by this author
Journal:
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society
Volume:
14
Issue:
3
Pages:
295-298
Publication date:
2006-03-05
DOI:
EISSN:
1522-9653
ISSN:
1063-4584
URN:
uuid:5ee949ae-6d70-4fe4-a7b5-7763e97e80b5
Source identifiers:
107298
Local pid:
pubs:107298

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