Asymmetric synthesis of alpha-alkylated aldehydes using terminal epoxide-derived chiral enamines.
- (Chemical Equation Presented) Effective discrimination: Efficient lithium amide-induced terminal epoxide-enamine transformation provides the first enamines capable of generating α-alkylated aldehydes with high asymmetric induction by intermolecular nucleophilic substitution (see scheme). © 2008 Wiley-VCH Verlag GmbH and Co. KGaA.
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