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Nephropathy in Zucker diabetic fat rat is associated with oxidative and nitrosative stress: prevention by chronic therapy with a peroxynitrite scavenger ebselen.

Abstract:

Zucker diabetic fat (ZDF) rats with the metabolic syndrome and hyperlipidemia develop focal and segmental sclerosis. The role of oxidative and nitrosative stress in the nephropathy in ZDF was studied. Renal histology, function, and immunohistologic and biochemical parameters of oxidative and nitrosative stress were evaluated at 8 and 22 wk of age in ZDF and Zucker lean (ZL) rats and after chronic treatment with ebselen, an antioxidant and peroxinitrite scavenger. At 8 wk, ZDF rats showed hype...

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Publication status:
Published

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Authors


Chander, PN More by this author
Gealekman, O More by this author
Brodsky, SV More by this author
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Journal:
Journal of the American Society of Nephrology : JASN
Volume:
15
Issue:
9
Pages:
2391-2403
Publication date:
2004-09-05
DOI:
EISSN:
1533-3450
ISSN:
1046-6673
URN:
uuid:5ed20ae8-76bb-47a1-847c-cf0c8f4ce4eb
Source identifiers:
342146
Local pid:
pubs:342146

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