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The relationship between striatal dopamine and anterior cingulate glutamate in first episode psychosis changes with antipsychotic treatment

Abstract:

The neuromodulator dopamine and excitatory neurotransmitter glutamate have both been implicated in the pathogenesis of psychosis, and dopamine antagonists remain the predominant treatment for psychotic disorders. To date no study has measured the effect of antipsychotics on both of these indices together, in the same population of people with psychosis. Striatal dopamine synthesis capacity (Kicer) and anterior cingulate glutamate were measured using 18F-DOPA positron emission to...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41398-023-02479-2

Authors


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Institution:
University of Oxford; Oxford Health NHS Foundation Trust
Division:
MSD
Department:
Psychiatry
Role:
Author
ORCID:
0000-0003-1102-2566
Publisher:
Springer Nature
Journal:
Translational Psychiatry More from this journal
Volume:
13
Issue:
1
Article number:
184
Publication date:
2023-05-31
Acceptance date:
2023-05-15
DOI:
EISSN:
2158-3188
Language:
English
Keywords:
Subjects:
Pubs id:
1337650
Local pid:
pubs:1337650
Deposit date:
2023-04-18

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