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Comparison between two peptide epitopes presented to cytotoxic T lymphocytes by HLA-A2. Evidence for discrete locations within HLA-A2.

Abstract:

An influenza B virus nucleoprotein (BNP) peptide, residues 82-94, defined by limited sequence homology with an HLA-A2-restricted peptide from influenza A matrix protein, was recognized by HLA-A2-restricted CTL. Reciprocal inhibition of T cell recognition by the two peptides suggest that the BNP peptide may have lower avidity for HLA-A2 molecules than the matrix peptide. The interaction between this peptide and HLA-A2 was explored by studying the CTL recognition of BNP 82-94 presented by mutan...

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Publication status:
Published

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Authors


Robbins, PA More by this author
Lettice, LA More by this author
Santos-Aguado, J More by this author
Rothbard, J More by this author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
143
Issue:
12
Pages:
4098-4103
Publication date:
1989-12-05
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:5eb5c48b-55f4-4eb8-8e97-fcde3ca5a7d6
Source identifiers:
35170
Local pid:
pubs:35170

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