- Abstract:
-
Mutations in the FBXO7 (PARK15) gene have been implicated in a juvenile form of parkinsonism termed parkinsonian pyramidal syndrome (PPS), characterized by Parkinsonian symptoms and pyramidal tract signs. FBXO7 (F-box protein only 7) is a subunit of the SCF (SKP1/cullin-1/F-box protein) E3 ubiquitin ligase complex, but its relevance and function in neurons remain to be elucidated. Here, we report that the E3 ligase FBXO7-SCF binds to and ubiquitinates the proteasomal subunit PSMA2. In additio...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted manuscript
- Publisher copy:
- 10.15252/embj.201593585
-
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- Publisher:
- EMBO Press Publisher's website
- Journal:
- EMBO Journal Journal website
- Volume:
- 35
- Issue:
- 18
- Pages:
- 2008-2025
- Publication date:
- 2016-08-05
- Acceptance date:
- 2016-07-06
- DOI:
- EISSN:
-
1460-2075
- ISSN:
-
0261-4189
- Pubs id:
-
pubs:639978
- URN:
-
uri:5eb59f9b-9a8c-4af2-a4ba-5273ad965b6a
- UUID:
-
uuid:5eb59f9b-9a8c-4af2-a4ba-5273ad965b6a
- Local pid:
- pubs:639978
- Paper number:
- 18
- Copyright holder:
- Vingill et al.
- Copyright date:
- 2016
- Notes:
- © 2016 The Authors. This is the accepted manuscript version of the article. The final version is available online from EMBO Press at: 10.15252/embj.201593585
Journal article
Loss of FBXO7 (PARK15) results in reduced proteasome activity and models a parkinsonism-like phenotype in mice
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Funding
Michael J. Fox Foundation for Parkinson's Research
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Max Planck Society
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Göttingen Graduate School for Neurosciences, Biophysics, and Molecular Biosciences (GGNB)
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RWTH Aachen University
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