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Journal article

Loss of FBXO7 (PARK15) results in reduced proteasome activity and models a parkinsonism-like phenotype in mice

Abstract:

Mutations in the FBXO7 (PARK15) gene have been implicated in a juvenile form of parkinsonism termed parkinsonian pyramidal syndrome (PPS), characterized by Parkinsonian symptoms and pyramidal tract signs. FBXO7 (F-box protein only 7) is a subunit of the SCF (SKP1/cullin-1/F-box protein) E3 ubiquitin ligase complex, but its relevance and function in neurons remain to be elucidated. Here, we report that the E3 ligase FBXO7-SCF binds to and ubiquitinates the proteasomal subunit PSMA2. In additio...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.15252/embj.201593585

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Brockelt, D More by this author
Lancelin, C More by this author
Tatenhorst, L More by this author
Dontcheva, G More by this author
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Michael J. Fox Foundation for Parkinson's Research More from this funder
Max Planck Society More from this funder
Göttingen Graduate School for Neurosciences, Biophysics, and Molecular Biosciences (GGNB) More from this funder
RWTH Aachen University More from this funder
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Publisher:
EMBO Press Publisher's website
Journal:
EMBO Journal Journal website
Volume:
35
Issue:
18
Pages:
2008-2025
Publication date:
2016-08-05
Acceptance date:
2016-07-06
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
Pubs id:
pubs:639978
URN:
uri:5eb59f9b-9a8c-4af2-a4ba-5273ad965b6a
UUID:
uuid:5eb59f9b-9a8c-4af2-a4ba-5273ad965b6a
Local pid:
pubs:639978
Paper number:
18

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