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Establishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a multiprotein complex containing Ets and GATA factors.

Abstract:

Stem cells are a central feature of metazoan biology. Haematopoietic stem cells (HSCs) represent the best-characterized example of this phenomenon, but the molecular mechanisms responsible for their formation remain obscure. The stem cell leukaemia (SCL) gene encodes a basic helix-loop-helix (bHLH) transcription factor with an essential role in specifying HSCs. Here we have addressed the transcriptional hierarchy responsible for HSC formation by characterizing an SCL 3' enhancer that targets ...

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Publication status:
Published

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Publisher copy:
10.1093/emboj/cdf286

Authors


Göttgens, B More by this author
Kinston, S More by this author
Delabesse, EC More by this author
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Journal:
The EMBO journal
Volume:
21
Issue:
12
Pages:
3039-3050
Publication date:
2002-06-05
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
URN:
uuid:5eb3b154-53a3-4eb6-979f-733fb98663e3
Source identifiers:
106370
Local pid:
pubs:106370

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