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Toxicity, tolerability & compliance of concurrent capecitabine or 5-fluorouracil in the radical management of anal cancer with single-dose mitomycin-C and intensity modulated radiation therapy: evaluation of a national cohort

Abstract:
Purpose Chemoradiotherapy (CRT) with mitomycin C (MMC) and 5-fluouracil (5-FU) is established as the standard of care for the radical management of patients with anal squamous cell carcinoma (ASCC). There is emerging use of the oral fluoropyrimidine-derivative capecitabine as an alternative to 5-FU despite limited evidence for its tolerability and toxicity. Methods & Materials A national cohort evaluation of anal cancer management within the United Kingd... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/j.ijrobp.2018.04.033

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Publisher:
Elsevier Publisher's website
Journal:
International Journal of Radiation Oncology*Biology*Physics Journal website
Volume:
101
Issue:
5
Pages:
1202-1211
Publication date:
2018-04-19
Acceptance date:
2018-04-10
DOI:
ISSN:
0360-3016
Pubs id:
pubs:836654
URN:
uri:5eb342de-9192-4b63-975f-6743b463cef0
UUID:
uuid:5eb342de-9192-4b63-975f-6743b463cef0
Local pid:
pubs:836654

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