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Sex- and tissue-specific functions of Drosophila doublesex transcription factor target genes.

Abstract:

Primary sex-determination "switches" evolve rapidly, but Doublesex (DSX)-related transcription factors (DMRTs) act downstream of these switches to control sexual development in most animal species. Drosophila dsx encodes female- and male-specific isoforms (DSX(F) and DSX(M)), but little is known about how dsx controls sexual development, whether DSX(F) and DSX(M) bind different targets, or how DSX proteins direct different outcomes in diverse tissues. We undertook genome-wide analyses to iden...

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Publication status:
Published
Peer review status:
Peer reviewed

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Authors


Jimenez, E More by this author
Whitworth, C More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
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Funding agency for:
Goodwin, SF
National Institutes of Health More from this funder
National Institute of Diabetes and Digestive and Kidney Diseases More from this funder
National Center for Biotechnology Information More from this funder
Publisher:
Cell Press Publisher's website
Journal:
Developmental cell Journal website
Volume:
31
Issue:
6
Pages:
761-773
Publication date:
2014-12-05
DOI:
EISSN:
1878-1551
ISSN:
1534-5807
URN:
uuid:5e8f06cb-26a4-4a69-93bf-4b44230ecd79
Source identifiers:
501557
Local pid:
pubs:501557

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