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Antiinflammatory effects of salmeterol/fluticasone propionate in chronic obstructive lung disease.

Abstract:

RATIONALE: No currently available treatment is reported to reduce the exaggerated airway wall inflammation of chronic obstructive pulmonary disease. OBJECTIVES: We tested the hypothesis that inhaled combined long-acting beta2-agonist (salmeterol) and corticosteroid (fluticasone propionate) will reduce inflammation. METHODS: Bronchial biopsies and induced sputum were taken from 140 current and former smokers (mean age, 64 yr) with moderate to severe disease, randomized in a 13-wk double-blind...

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Publisher copy:
10.1164/rccm.200508-1321oc

Authors


Barnes, NC More by this author
Pavord, ID More by this author
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Journal:
American journal of respiratory and critical care medicine
Volume:
173
Issue:
7
Pages:
736-743
Publication date:
2006-04-05
DOI:
EISSN:
1535-4970
ISSN:
1073-449X
URN:
uuid:5e8ab08b-84d5-4576-8c91-9048dda8781f
Source identifiers:
435309
Local pid:
pubs:435309

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