RORγt+ innate lymphoid cells promote lymph node metastasis of breast cancers.
Cancer cells tend to metastasize first to tumor-draining lymph nodes, but the mechanisms mediating cancer cell invasion into the lymphatic vasculature remain little understood. Here, we show that in the human breast tumor microenvironment (TME), the presence of increased numbers of RORγt+ group 3 innate lymphoid cells (ILC3) correlates with an increased likelihood of lymph node metastasis. In a preclinical mouse model of breast cancer, CCL21-mediated recruitment of ILC3 to tumors stimulated t...Expand abstract
- Publication status:
- Peer review status:
- Peer reviewed
- Accepted manuscript
- American Association for Cancer Research Publisher's website
- Cancer Research Journal website
- Publication date:
- Acceptance date:
- Pubs id:
- Local pid:
- Copyright holder:
- American Association for Cancer Research
- Copyright date:
- © 2017 American Association for Cancer Research.