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Journal article

RORγt+ innate lymphoid cells promote lymph node metastasis of breast cancers.

Abstract:

Cancer cells tend to metastasize first to tumor-draining lymph nodes, but the mechanisms mediating cancer cell invasion into the lymphatic vasculature remain little understood. Here, we show that in the human breast tumor microenvironment (TME), the presence of increased numbers of RORγt+ group 3 innate lymphoid cells (ILC3) correlates with an increased likelihood of lymph node metastasis. In a preclinical mouse model of breast cancer, CCL21-mediated recruitment of ILC3 to tumors stimulated t...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1158/0008-5472.can-16-0598

Authors


Flores-Borja, F More by this author
Monypenny, J More by this author
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Publisher:
American Association for Cancer Research Publisher's website
Journal:
Cancer Research Journal website
Volume:
77
Issue:
5
Pages:
1083-1096
Publication date:
2017-01-05
Acceptance date:
2016-12-10
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
Pubs id:
pubs:670928
URN:
uri:5e74a5d0-b073-4021-9137-554dda8784c8
UUID:
uuid:5e74a5d0-b073-4021-9137-554dda8784c8
Local pid:
pubs:670928

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