Irreversibility of mitotic exit is the consequence of systems-level feedback.

Journal article

The eukaryotic cell cycle comprises an ordered series of events, orchestrated by the activity of cyclin-dependent kinases (Cdks), leading from chromosome replication during S phase to their segregation in mitosis. The unidirectionality of cell-cycle transitions is fundamental for the successful completion of this cycle. It is thought that irrevocable proteolytic degradation of key cell-cycle regulators makes cell-cycle transitions irreversible, thereby enforcing directionality. Here we have e...

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Authors: López-Avilés, S; Kapuy, O; Novák, B; Uhlmann, F

• Publication status: Published
• Journal: Nature
• Volume: 459
• Issue: 7246
• Pages: 592-595
• Publication date: 2009-05-01
• DOI: 10.1038/nature07984
• EISSN: 1476-4687
• ISSN: 0028-0836
• Language: English
• Keywords: Computer Simulation; G1 Phase; Cyclin-Dependent Kinase Inhibitor Proteins; Mitosis; Systems Biology; Cyclin-Dependent Kinases; Saccharomyces cerevisiae; Feedback, Physiological; Saccharomyces cerevisiae Proteins; Cyclins; Cyclin B