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Salmonella Typhimurium utilizes a T6SS-mediated antibacterial weapon to establish in the host gut.

Abstract:

The mammalian gastrointestinal tract is colonized by a high-density polymicrobial community where bacteria compete for niches and resources. One key competition strategy includes cell contact-dependent mechanisms of interbacterial antagonism, such as the type VI secretion system (T6SS), a multiprotein needle-like apparatus that injects effector proteins into prokaryotic and/or eukaryotic target cells. However, the contribution of T6SS antibacterial activity during pathogen invasion of the gut...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1073/pnas.1608858113

Authors


Flaugnatti, N More by this author
More by this author
Department:
Oxford, MSD, NDORMS, KIR
Jacobson, A More by this author
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Burroughs Wellcome Fund More from this funder
French National Center for Scientific Research More from this funder
Aix-Marseille University More from this funder
French National Research Agency More from this funder
Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences Journal website
Volume:
113
Issue:
34
Pages:
E5044-E5051
Publication date:
2016-08-05
DOI:
EISSN:
0027-8424
ISSN:
1091-6490
Pubs id:
pubs:638861
URN:
uri:5e5e0fb7-a048-441d-83ed-e9c9e01f8ff7
UUID:
uuid:5e5e0fb7-a048-441d-83ed-e9c9e01f8ff7
Local pid:
pubs:638861

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