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Capacitance measurements of exocytosis in mouse pancreatic alpha-, beta- and delta-cells within intact islets of Langerhans.

Abstract:

Capacitance measurements of exocytosis were applied to functionally identified alpha-, beta- and delta-cells in intact mouse pancreatic islets. The maximum rate of capacitance increase in beta-cells during a depolarization to 0 mV was equivalent to 14 granules s(-1), <5% of that observed in isolated beta-cells. Beta-cell secretion exhibited bell-shaped voltage dependence and peaked at +20 mV. At physiological membrane potentials (up to approximately -20 mV) the maximum rate of release was ...

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Publication status:
Published

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Authors


Eliasson, L More by this author
Galvanovskis, J More by this author
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Journal:
The Journal of physiology
Volume:
556
Issue:
Pt 3
Pages:
711-726
Publication date:
2004-05-05
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
URN:
uuid:5e49de99-edd0-457b-82c2-ccea8fa94ad4
Source identifiers:
4486
Local pid:
pubs:4486

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