- Abstract:
-
Capacitance measurements of exocytosis were applied to functionally identified alpha-, beta- and delta-cells in intact mouse pancreatic islets. The maximum rate of capacitance increase in beta-cells during a depolarization to 0 mV was equivalent to 14 granules s(-1), <5% of that observed in isolated beta-cells. Beta-cell secretion exhibited bell-shaped voltage dependence and peaked at +20 mV. At physiological membrane potentials (up to approximately -20 mV) the maximum rate of release was ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1113/jphysiol.2003.059675
-
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- Journal:
- The Journal of physiology
- Volume:
- 556
- Issue:
- Pt 3
- Pages:
- 711-726
- Publication date:
- 2004-05-05
- DOI:
- EISSN:
-
1469-7793
- ISSN:
-
0022-3751
- URN:
-
uuid:5e49de99-edd0-457b-82c2-ccea8fa94ad4
- Source identifiers:
-
4486
- Local pid:
- pubs:4486
- Language:
- English
- Keywords:
- Copyright date:
- 2004
Journal article
Capacitance measurements of exocytosis in mouse pancreatic alpha-, beta- and delta-cells within intact islets of Langerhans.
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