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Thesis

Circadian characterisation of the transcription factor Zfhx3 utilising a conditional mutagenesis approach

Abstract:

Previous work revealed an important role for the transcription factor ZFHX3 in circadian biology. A dominant missense mutation in the gene (Zfhx3Sci) results in a short circadian period in constant conditions and altered sleep homeostasis. However, constitutive knock-outs of this gene are embryonic lethal, limiting experimental characterisation options. In this thesis, the role of Zfhx3 in circadian rhythm regulation throughout the lifespan of the mouse is examined using conditi...

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Ashleigh G Wilcox More by this author

Contributors

Department:
MRC Harwell
Role:
Supervisor
Department:
dpag/MRC
Role:
Supervisor
Department:
MRC Harwell
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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