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RELAx - REstricted versus Liberal positive end-expiratory pressure in patients without ARDS: protocol for a randomized controlled trial

Abstract:

Background

Evidence for benefit of high positive end-expiratory pressure (PEEP) is largely lacking for invasively ventilated, critically ill patients with uninjured lungs. We hypothesize that ventilation with low PEEP is noninferior to ventilation with high PEEP with regard to the number of ventilator-free days and being alive at day 28 in this population.

Methods/Design

The “REstricted versus Liberal positive end-expiratory pressure in patients without ARDS” tria...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s13063-018-2640-5

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Role:
Author
ORCID:
0000-0001-5632-1290
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Dutch Organization for Scientific Research More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
Trials Journal website
Volume:
19
Issue:
1
Pages:
272
Publication date:
2018-05-09
Acceptance date:
2018-04-10
DOI:
EISSN:
1745-6215
ISSN:
1745-6215
Pubs id:
pubs:852986
URN:
uri:5e0495c5-4613-453a-860c-a1a282f16112
UUID:
uuid:5e0495c5-4613-453a-860c-a1a282f16112
Local pid:
pubs:852986

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