Journal article
Coupled activation and degradation of eEF2K regulates protein synthesis in response to genotoxic stress.
- Abstract:
-
The kinase eEF2K [eukaryotic elongation factor 2 (eEF2) kinase] controls the rate of peptide chain elongation by phosphorylating eEF2, the protein that mediates the movement of the ribosome along the mRNA by promoting translocation of the transfer RNA from the A to the P site in the ribosome. eEF2K-mediated phosphorylation of eEF2 on threonine 56 (Thr⁵⁶) decreases its affinity for the ribosome, thereby inhibiting elongation. Here, we show that in response to genotoxic stress, eEF2K was activa...
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- Publication status:
- Published
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- Publisher copy:
- 10.1126/scisignal.2002718
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Authors
Bibliographic Details
- Journal:
- Science signaling
- Volume:
- 5
- Issue:
- 227
- Pages:
- ra40
- Publication date:
- 2012-06-01
- DOI:
- EISSN:
-
1937-9145
- ISSN:
-
1937-9145
- Source identifiers:
-
384552
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:384552
- UUID:
-
uuid:5e01a2f8-0812-4bd0-98d9-7f4897c5fcae
- Local pid:
- pubs:384552
- Deposit date:
- 2013-11-16
Terms of use
- Copyright date:
- 2012
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