Journal article icon

Journal article

Coupled activation and degradation of eEF2K regulates protein synthesis in response to genotoxic stress.

Abstract:

The kinase eEF2K [eukaryotic elongation factor 2 (eEF2) kinase] controls the rate of peptide chain elongation by phosphorylating eEF2, the protein that mediates the movement of the ribosome along the mRNA by promoting translocation of the transfer RNA from the A to the P site in the ribosome. eEF2K-mediated phosphorylation of eEF2 on threonine 56 (Thr⁵⁶) decreases its affinity for the ribosome, thereby inhibiting elongation. Here, we show that in response to genotoxic stress, eEF2K was activa...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1126/scisignal.2002718

Authors


Expand authors...
Journal:
Science signaling
Volume:
5
Issue:
227
Pages:
ra40
Publication date:
2012-06-05
DOI:
EISSN:
1937-9145
ISSN:
1937-9145
URN:
uuid:5e01a2f8-0812-4bd0-98d9-7f4897c5fcae
Source identifiers:
384552
Local pid:
pubs:384552

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP