- Abstract:
-
The kinase eEF2K [eukaryotic elongation factor 2 (eEF2) kinase] controls the rate of peptide chain elongation by phosphorylating eEF2, the protein that mediates the movement of the ribosome along the mRNA by promoting translocation of the transfer RNA from the A to the P site in the ribosome. eEF2K-mediated phosphorylation of eEF2 on threonine 56 (Thr⁵⁶) decreases its affinity for the ribosome, thereby inhibiting elongation. Here, we show that in response to genotoxic stress, eEF2K was activa...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1126/scisignal.2002718
-
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- Journal:
- Science signaling
- Volume:
- 5
- Issue:
- 227
- Pages:
- ra40
- Publication date:
- 2012-06-05
- DOI:
- EISSN:
-
1937-9145
- ISSN:
-
1937-9145
- URN:
-
uuid:5e01a2f8-0812-4bd0-98d9-7f4897c5fcae
- Source identifiers:
-
384552
- Local pid:
- pubs:384552
- Language:
- English
- Keywords:
- Copyright date:
- 2012
Journal article
Coupled activation and degradation of eEF2K regulates protein synthesis in response to genotoxic stress.
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