Docosahexaenoic acid and 17 beta-estradiol co-treatment is more effective than 17 beta-estradiol alone in maintaining bone post-ovariectomy.

Journal article

Bone-protective effects of combined treatment with long chain polyunsaturated fatty acids (LCPUFAs) and estrogenic compounds following ovariectomy have previously been reported. Recent evidence suggests the n-3 LCPUFA docosahexaenoic acid (DHA, 22:6n-3) is particularly bone-protective. The aim of this study was to determine whether combined treatment with DHA and estrogenic compounds has a beneficial effect on bone mass in ovariectomized (OVX) rats. Rats were randomized into 9 groups and eith...

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Authors: Poulsen, R; Moughan, P; Kruger, M

• Publication status: Published
• Journal: Experimental biology and medicine (Maywood, N.J.)
• Volume: 233
• Issue: 5
• Pages: 592-602
• Publication date: 2008-05-01
• DOI: 10.3181/0709-rm-259
• EISSN: 1535-3699
• ISSN: 1535-3702
• Language: English
• Keywords: Densitometry; Rats, Sprague-Dawley; Osteocalcin; Bone Density; Female; Rats; Animals; Erythrocytes; Bone and Bones; Body Weight; Interleukin-6; Estradiol; Docosahexaenoic Acids; Biomechanics; Ovariectomy; Feeding Behavior; Fatty Acids