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Journal article

The microbiome of infants recruited to a randomised placebo-controlled probiotic trial (PiPS Trial)

Abstract:

The microbial dysbiosis associated with necrotizing enterocolitis (NEC) in preterm infants suggests that early exposure to probiotics may decrease and antibiotics may increase NEC risk. However, administration of Bifidobacterium breve strain BBG-001 to preterm infants did not affect NEC incidence in a multicenter randomised controlled phase 3 trial (PiPS trial). Using a subset of these subjects we compared the fecal microbiome of probiotic and placebo groups and assessed the impact of early a...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.ebiom.2017.05.019

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Department:
Oxford, MSD, Nuffield Department of Population Health, NPEU
More by this author
Department:
Oxford, MSD, Nuffield Department of Population Health, NPEU
More by this author
Department:
Oxford, MSD, Nuffield Department of Population Health, NPEU
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Publisher:
Elsevier Publisher's website
Journal:
EBioMedicine Journal website
Volume:
20
Pages:
255-262
Publication date:
2017-05-17
Acceptance date:
2017-05-15
DOI:
ISSN:
2352-3964
Pubs id:
pubs:698723
URN:
uri:5dfb7c1a-897c-41b2-82e0-a4163028032d
UUID:
uuid:5dfb7c1a-897c-41b2-82e0-a4163028032d
Local pid:
pubs:698723

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