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A crucial role for bone morphogenetic protein-Smad1 signalling in the DNA damage response.

Abstract:

DNA damage and the elicited cellular response underlie the etiology of tumorigenesis and ageing. Yet, how this response integrates inputs from cells' environmental cues remains underexplored. Here we report that the BMP-Smad1 pathway, which is essential for embryonic development and tissue homeostasis, has an important role in the DNA damage response and oncogenesis. On genotoxic stress, Atm phosphorylates BMPs-activated Smad1 in the nucleus on S239, which disrupts Smad1 interaction with prot...

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Publication status:
Published

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Publisher copy:
10.1038/ncomms1832

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Journal:
Nature communications
Volume:
3
Pages:
836
Publication date:
2012
DOI:
EISSN:
2041-1723
ISSN:
2041-1723
URN:
uuid:5deb1a39-7495-4b9c-ba6f-f442a7b580f9
Source identifiers:
340657
Local pid:
pubs:340657

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