Journal article
Molecular dynamics study of water and Na⁺ ions in models of the pore region of the nicotinic acetylcholine receptor
- Abstract:
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The nicotinic acetylcholine receptor (nAChR) is an integral membrane protein that forms ligand-gated and cation-selective channels. The central pore is lined by a bundle of five approximately parallel M2 helices, one from each subunit. Candidate model structures of the solvated pore region of a homopentameric (α7)5 nAChR channel in the open state, and in two possible forms of the closed state, have been studied using molecular dynamics simulations with restraining potentials. It is...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 2.0MB)
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- Publisher copy:
- 10.1016/S0006-3495(97)78169-4
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Funding
Wellcome Trust
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Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Biophysical Journal Journal website
- Volume:
- 73
- Issue:
- 3
- Pages:
- 1364–1381
- Publication date:
- 1997-09-01
- DOI:
- ISSN:
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0006-3495
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:5de8686a-588f-49e8-bb49-cb059f558a65
- Local pid:
- ora:8112
- Deposit date:
- 2014-02-26
Related Items
Terms of use
- Copyright holder:
- Biophysical Society
- Copyright date:
- 1997
- Notes:
- Copyright © 1997 The Biophysical Society. Published by Elsevier Inc. All rights reserved. Re-use of this article is permitted in accordance with the Terms and Conditions set out at http://www.elsevier.com/open-access/userlicense/1.0/ (accessed 24/02/2014).
- Licence:
- Other
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