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Molecular dynamics study of water and Na⁺ ions in models of the pore region of the nicotinic acetylcholine receptor

Abstract:

The nicotinic acetylcholine receptor (nAChR) is an integral membrane protein that forms ligand-gated and cation-selective channels. The central pore is lined by a bundle of five approximately parallel M2 helices, one from each subunit. Candidate model structures of the solvated pore region of a homopentameric (α7)5 nAChR channel in the open state, and in two possible forms of the closed state, have been studied using molecular dynamics simulations with restraining potentials. It is...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/S0006-3495(97)78169-4

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author

Contributors

Wellcome Trust More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Biophysical Journal Journal website
Volume:
73
Issue:
3
Pages:
1364–1381
Publication date:
1997-09-01
DOI:
ISSN:
0006-3495
Language:
English
Keywords:
Subjects:
UUID:
uuid:5de8686a-588f-49e8-bb49-cb059f558a65
Local pid:
ora:8112
Deposit date:
2014-02-26

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