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Thesis

Studies on HIF hydroxylases

Abstract:

Hypoxia-inducible factor (HIF) is the master regulator of genes involved in adaptation to hypoxia. The stability and transcriptional activity of HIF are regulated by post-translational hydroxylations: prolyl hydroxylation by the prolyl hydroxylase domain-containing enzymes PHD1 – 3 earmarks HIF for proteasomal degradation, whilst asparaginyl hydroxylation by factor inhibiting HIF (FIH) blocks the interaction of HIF with the transcriptional coactivators p300/CBP. The PHDs and FIH hydroxylat...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Oxford college:
Merton College
Role:
Author

Contributors

Division:
MSD
Department:
NDM
Role:
Supervisor
Publication date:
2008
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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