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Aruncin B: synthetic studies, structural reassignment and biological evaluation

Abstract:

A ring−closing alkene metathesis (RCM) / oxyselenation−selenoxide elimination sequence was established to the sodium salts E- and Z-25 of the originally proposed structure for the recently isolated cytotoxin aruncin B (1), as well as to the sodium salt Z-34 of a related ethyl ether regioisomer; however, none of their corresponding free acids could be obtained. Their acid sensitivity, together with detailed analysis of the spectroscopic data indicated that profound structural revision was nece...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/chem.201702949

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Author
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Grant:
People Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme (FP7/2007-2013) under REA grant agreement 316955
National Institute for Health Research More from this funder
Publisher:
Wiley Publisher's website
Journal:
Chemistry - A European Journal Journal website
Volume:
23
Issue:
65
Pages:
16525–16534
Publication date:
2017-10-30
Acceptance date:
2017-08-14
DOI:
EISSN:
1521-3765
ISSN:
0947-6539
Keywords:
Pubs id:
pubs:718301
UUID:
uuid:5db82ae5-b006-44c3-ab99-73f8ed591460
Local pid:
pubs:718301
Deposit date:
2017-08-16

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