A ring−closing alkene metathesis (RCM) / oxyselenation−selenoxide elimination sequence was established to the sodium salts E- and Z-25 of the originally proposed structure for the recently isolated cytotoxin aruncin B (1), as well as to the sodium salt Z-34 of a related ethyl ether regioisomer; however, none of their corresponding free acids could be obtained. Their acid sensitivity, together with detailed analysis of the spectroscopic data indicated that profound structural revision was nece...Expand abstract
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- People Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme (FP7/2007-2013) under REA grant agreement 316955
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- Ribaucourt et al.
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Aruncin B: synthetic studies, structural reassignment and biological evaluation
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