Diminishing returns from beneficial mutations and pervasive epistasis shape the fitness landscape for rifampicin resistance in Pseudomonas aeruginosa.

Journal article

Because adaptation depends upon the fixation of novel beneficial mutations, the fitness effects of beneficial mutations that are substituted by selection are key to our understanding of the process of adaptation. In this study, we experimentally investigated the fitness effects of beneficial mutations that are substituted when populations of the pathogenic bacterium Pseudomonas aeruginosa adapt to the antibiotic rifampicin. Specifically, we isolated the first beneficial mutation to be fixed b...

Expand abstract

Authors: Maclean, C; Perron, G; Gardner, A

• Publication status: Published
• Journal: Genetics
• Volume: 186
• Issue: 4
• Pages: 1345-1354
• Publication date: 2010-12-01
• DOI: 10.1534/genetics.110.123083
• EISSN: 1943-2631
• ISSN: 0016-6731
• Language: English
• Keywords: Epistasis, Genetic; Biological Evolution; Pseudomonas aeruginosa; Genetic Fitness; Mutation; Genotype; Rifampin; Drug Resistance, Microbial