Coagulation and metastasis: what does the experimental literature tell us?

Journal article

Inhibition of coagulation greatly limits cancer metastasis in many experimental models. Cancer cells trigger coagulation, through expression of tissue factor or P-selectin ligands that have correlated with worse prognosis in human clinical studies. Cancer cells also affect coagulation through expression of thrombin and release of microparticles that augment coagulation. In the cancer-bearing host, coagulation facilitates tumour progression through release of platelet granule contents, inhibit...

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Authors: Gil-Bernabé, A; Lucotti, S; Muschel, R

• Publication status: Published
• Journal: British journal of haematology
• Volume: 162
• Issue: 4
• Pages: 433-441
• Publication date: 2013-08-01
• DOI: 10.1111/bjh.12381
• EISSN: 1365-2141
• ISSN: 0007-1048
• Language: English
• Keywords: Neoplasm Metastasis; Anticoagulants; Humans; Neoplasms, Experimental; Blood Platelets; Blood Coagulation; P-Selectin; Thromboplastin; Neoplasm Proteins; Rats; Thrombin; Cytoplasmic Granules; Killer Cells, Natural; Lung Neoplasms; Neuraminidase; Animals; Hirudins; Macrophages; Neoplastic Cells, Circulating; Platelet Aggregation Inhibitors; Thrombophilia; Platelet Activation; Mice; Cysteine Endopeptidases