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Mitochondrial membrane remodelling regulated by a conserved rhomboid protease.

Abstract:

Rhomboid proteins are intramembrane serine proteases that activate epidermal growth factor receptor (EGFR) signalling in Drosophila. Rhomboids are conserved throughout evolution, and even in eukaryotes their existence in species with no EGFRs implies that they must have additional roles. Here we report that Saccharomyces cerevisiae has two rhomboids, which we have named Rbd1p and Rbd2p. RBD1 deletion results in a respiratory defect; consistent with this, Rbd1p is localized in the inner mitoch...

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Publication status:
Published

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Publisher copy:
10.1038/nature01633

Authors


McQuibban, GA More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Nature
Volume:
423
Issue:
6939
Pages:
537-541
Publication date:
2003-05-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:5da24ac1-02d9-4558-bbba-f0e72f92b548
Source identifiers:
273508
Local pid:
pubs:273508

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