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Journal article

Lack of noggin expression by cancer cells is a determinant of the osteoblast response in bone metastases.

Abstract:

Prostate and mammary cancer bone metastases can be osteoblastic or osteolytic, but the mechanisms determining these features are unclear. Bone morphogenetic and Wnt proteins are osteoinductive molecules. Their activity is modulated by antagonists such as noggin and dickkopf-1. Differential expression analysis of bone morphogenetic and Wnt protein antagonists in human prostate and mammary cancer cell lines showed that osteolytic cell lines constitutively express in vitro noggin and dickkopf-1 ...

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Publication status:
Published

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Publisher copy:
10.2353/ajpath.2007.051276

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Journal:
The American journal of pathology
Volume:
170
Issue:
1
Pages:
160-175
Publication date:
2007-01-05
DOI:
EISSN:
1525-2191
ISSN:
0002-9440
URN:
uuid:5d9e3495-0479-4139-b091-8f2af3e8e412
Source identifiers:
120720
Local pid:
pubs:120720

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