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Anti-antimicrobial peptides: folding-mediated host defense antagonists.

Abstract:

Antimicrobial or host defense peptides are innate immune regulators found in all multicellular organisms. Many of them fold into membrane-bound α-helices and function by causing cell wall disruption in microorganisms. Herein we probe the possibility and functional implications of antimicrobial antagonism mediated by complementary coiled-coil interactions between antimicrobial peptides and de novo designed antagonists: anti-antimicrobial peptides. Using sequences from native helical families s...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m113.459560

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Journal:
The Journal of biological chemistry
Volume:
288
Issue:
28
Pages:
20162-20172
Publication date:
2013-07-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:5d95390e-5411-4f59-8547-81adec252745
Source identifiers:
413521
Local pid:
pubs:413521

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