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Do C-H...O hydrogen bonds contribute to the stability of nucleic acid base pairs?

Abstract:
The possible formation of inter-base C-H.O hydrogen bonds in A.T, A.U and certain non-Watson-Crick base pairs is examined. A geometrical analysis in conjunction with implications for the thermodynamic stability of the base pairs suggests that C-H.O hydrogen bonds could form in nucleic acid base pairs. They may alleviate destabilizing interactions that would arise if an unsatisfied hydrogen-bond acceptor were present and mediate secondary hydrogen-bonding effects in these base pairs.
Publication status:
Published

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Publisher copy:
10.1107/s0907444994004713

Authors


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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
Journal:
Acta crystallographica. Section D, Biological crystallography
Volume:
51
Issue:
Pt 2
Pages:
136-139
Publication date:
1995-03-05
DOI:
EISSN:
1399-0047
ISSN:
0907-4449
URN:
uuid:5d76ae32-d94d-44e0-81de-59f52e2f53d7
Source identifiers:
400355
Local pid:
pubs:400355
Language:
English

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