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Journal article

Properties of [(111)In]-labeled HIV-1 tat peptide radioimmunoconjugates in tumor-bearing mice following intravenous or intratumoral injection.

Abstract:

INTRODUCTION: Our objective was to evaluate the tumor and normal tissue distribution and nuclear importation properties of [(111)In]-mouse IgG (mIgG) conjugated to tat peptides (GRKKRRQRRRPPQGYG) in athymic mice with subcutaneous BT-474 human breast cancer xenografts. METHODS: Tumor and normal tissue uptake was compared after intravenous (iv) or intratumoral injection of [(111)In]-mIgG-tat and [(111)In]-mIgG. Area under the curve (AUC) was estimated for blood, liver, spleen, kidneys and tumo...

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Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
Journal:
Nuclear medicine and biology
Volume:
35
Issue:
1
Pages:
101-110
Publication date:
2008-01-05
DOI:
EISSN:
1872-9614
ISSN:
0969-8051
URN:
uuid:5d76366e-f8e3-4d4a-9de6-f22afbc568f8
Source identifiers:
260823
Local pid:
pubs:260823

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