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The value of animal models for drug development in multiple sclerosis

Abstract:

The rodent model for multiple sclerosis, experimental allergic (autoimmune) encephalomyelitis (EAE), has been used to dissect molecular mechanisms of the autoimmune inflammatory response, and hence to devise and test new therapies for multiple sclerosis. Clearly, artificial immunization against myelin may not necessarily reproduce all the pathogenetic mechanisms operating in the human disease, but most therapies tested in multiple sclerosis patients are nevertheless based on concepts derived ...

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Publisher copy:
10.1093/brain/awl083

Authors


Friese, MA More by this author
Montalban, X More by this author
Willcox, N More by this author
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Journal:
Brain
Volume:
129
Issue:
8
Pages:
1940-1952
Publication date:
2006-08-05
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
URN:
uuid:5d744c86-ab1c-48bf-967e-7a8e0613b119
Source identifiers:
285255
Local pid:
pubs:285255

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