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Population Pharmacokinetics and Antimalarial Pharmacodynamics of Piperaquine in Patients With Plasmodium vivax Malaria in Thailand.

Abstract:

Dihydroartemisinin-piperaquine is an effective drug in the treatment of Plasmodium falciparum and P. vivax malaria. The objective of this study was to evaluate the population pharmacokinetics and pharmacodynamics of piperaquine in patients with P. vivax malaria in Thailand after a standard regimen of dihydroartemisinin-piperaquine to determine whether residual piperaquine prevents or delays the emergence of P. vivax relapse. Sparse blood samples were collected from 116 patients. Piperaquine p...

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Publisher copy:
10.1038/psp.2014.29

Authors


Tarning, J More by this author
Hanpithakpong, W More by this author
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Publisher:
Nature Publishing Group
Journal:
CPT: pharmacometrics and systems pharmacology
Volume:
3
Issue:
8
Pages:
e132
Publication date:
2014
DOI:
EISSN:
2163-8306
URN:
uuid:5d7182b1-af50-400e-b105-1c768d98e6de
Source identifiers:
482562
Local pid:
pubs:482562
Language:
English

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