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Tissue inhibitors of metalloproteinases: evolution, structure and function.

Abstract:

The matrix metalloproteinases (MMPs) play a key role in the normal physiology of connective tissue during development, morphogenesis and wound healing, but their unregulated activity has been implicated in numerous disease processes including arthritis, tumor cell metastasis and atherosclerosis. An important mechanism for the regulation of the activity of MMPs is via binding to a family of homologous proteins referred to as the tissue inhibitors of metalloproteinases (TIMP-1 to TIMP-4). The t...

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Publication status:
Published

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Authors


Dinakarpandian, D More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
Biochimica et biophysica acta
Volume:
1477
Issue:
1-2
Pages:
267-283
Publication date:
2000-03-05
DOI:
ISSN:
0006-3002
URN:
uuid:5d69c459-1d2a-4391-928e-28f80358a47d
Source identifiers:
226667
Local pid:
pubs:226667

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