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Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis

Abstract:

Endometriosis is a common gynecological disease associated with pelvic pain and subfertility. We conducted a genome-wide association study (GWAS) in 3,194 individuals with surgically confirmed endometriosis (cases) and 7,060 controls from Australia and the UK. Polygenic predictive modeling showed significantly increased genetic loading among 1,364 cases with moderate to severe endometriosis. The strongest association signal was on 7p15.2 (rs12700667) for 'all' endometriosis (P = 2.6 ×- 10-7, ...

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Publisher copy:
10.1038/ng.731

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Journal:
Nature Genetics
Volume:
43
Issue:
1
Pages:
51-54
Publication date:
2011-01-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:5d699428-ad03-4667-aef2-d0ce18a9e1f3
Source identifiers:
112692
Local pid:
pubs:112692
Language:
English

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