Journal article icon

Journal article

Iterative Correction of Reference Nucleotides (iCORN) using second generation sequencing technology.

Abstract:

MOTIVATION: The accuracy of reference genomes is important for downstream analysis but a low error rate requires expensive manual interrogation of the sequence. Here, we describe a novel algorithm (Iterative Correction of Reference Nucleotides) that iteratively aligns deep coverage of short sequencing reads to correct errors in reference genome sequences and evaluate their accuracy. RESULTS: Using Plasmodium falciparum (81% A + T content) as an extreme example, we show that the algorithm is ...

Expand abstract
Publication status:
Published

Actions


Access Document


Files:
Publisher copy:
10.1093/bioinformatics/btq269

Authors


Journal:
Bioinformatics (Oxford, England)
Volume:
26
Issue:
14
Pages:
1704-1707
Publication date:
2010-07-05
DOI:
EISSN:
1367-4811
ISSN:
1367-4803
URN:
uuid:5d4f43d3-8594-4aa6-8166-6e3f27688e0c
Source identifiers:
94893
Local pid:
pubs:94893

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP