Journal article
Iterative Correction of Reference Nucleotides (iCORN) using second generation sequencing technology.
- Abstract:
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MOTIVATION: The accuracy of reference genomes is important for downstream analysis but a low error rate requires expensive manual interrogation of the sequence. Here, we describe a novel algorithm (Iterative Correction of Reference Nucleotides) that iteratively aligns deep coverage of short sequencing reads to correct errors in reference genome sequences and evaluate their accuracy. RESULTS: Using Plasmodium falciparum (81% A + T content) as an extreme example, we show that the algorithm is ...
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- Publication status:
- Published
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(pdf, 307.5KB)
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- Publisher copy:
- 10.1093/bioinformatics/btq269
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Authors
Bibliographic Details
- Journal:
- Bioinformatics (Oxford, England)
- Volume:
- 26
- Issue:
- 14
- Pages:
- 1704-1707
- Publication date:
- 2010-07-01
- DOI:
- EISSN:
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1367-4811
- ISSN:
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1367-4803
- Source identifiers:
-
94893
Item Description
- Language:
- English
- Keywords:
- UUID:
-
uuid:5d4f43d3-8594-4aa6-8166-6e3f27688e0c
- Local pid:
- pubs:94893
- Deposit date:
- 2012-12-19
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- Copyright date:
- 2010
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