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Distinct pathways of LPS-induced NF-kappa B activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of MyD88 and Mal/TIRAP.

Abstract:

How lipopolysaccharide (LPS) signals through toll-like receptors (TLRs) to induce nuclear factor (NF)-kappa B inflammatory cytokines in sepsis remains unclear. Major candidates for that process are myeloid differentiation protein 88 (MyD88) and MyD88 adaptor-like/TIR domain-containing adaptor protein (Mal/TIRAP) but their role needs to be further defined. Here, we have examined the role of MyD88 and Mal/TIRAP in primary human cells of nonmyeloid and myeloid origin as physiologically relevant ...

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Publication status:
Published

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Publisher copy:
10.1182/blood-2003-04-1356

Authors


Andreakos, E More by this author
Lundberg, A More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
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Journal:
Blood
Volume:
103
Issue:
6
Pages:
2229-2237
Publication date:
2004-03-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:5d4c60be-8865-49fa-b69a-7643e3c1ecf9
Source identifiers:
224603
Local pid:
pubs:224603

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