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Alpha-glucosidases inhibitors impair HCV pseudoparticles morphogenesis, prevent viral secretion and entry into hepatoma cells

Abstract:

The morphogenesis of HCV belongs to steps of the viral cycle that have not yet been targeted by antiviral strategies. With the lack of an efficient and reliable culture system able to produce and secrete HCV virions, we use two complementary approaches to study the effect of c~-gluensidase inhibitors on HCV morphogenesis, secretion and entry. These two approaches have allowed us to demonstrate tile mechanism of tile antiviral effect of O,-glucosidase inhibitors on HCV glyenprotein folding and...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Authors


Vuillermoz, I More by this author
Bartosch, B More by this author
Cosset, F-L More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
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Publisher:
Elsevier Publisher's website
Volume:
42
Pages:
9-9
Publication date:
2005-04-05
DOI:
ISSN:
0168-8278
URN:
uuid:5d46571a-ac14-4a36-a321-78a476e1267f
Source identifiers:
100916
Local pid:
pubs:100916

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