Conference item icon

Conference item

Alpha-glucosidases inhibitors impair HCV pseudoparticles morphogenesis, prevent viral secretion and entry into hepatoma cells

Abstract:

The morphogenesis of HCV belongs to steps of the viral cycle that have not yet been targeted by antiviral strategies. With the lack of an efficient and reliable culture system able to produce and secrete HCV virions, we use two complementary approaches to study the effect of c~-gluensidase inhibitors on HCV morphogenesis, secretion and entry. These two approaches have allowed us to demonstrate tile mechanism of tile antiviral effect of O,-glucosidase inhibitors on HCV glyenprotein folding and...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
Publisher:
Elsevier Publisher's website
Host title:
40th Annual Meeting Of The European Association For The Study Of The Liver
Volume:
42
Pages:
9-9
Publication date:
2005-04-01
DOI:
ISSN:
0168-8278
Pubs id:
pubs:100916
UUID:
uuid:5d46571a-ac14-4a36-a321-78a476e1267f
Local pid:
pubs:100916
Source identifiers:
100916
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP