Journal article
V3: HIV's switch-hitter.
- Abstract:
-
The third variable region, V3, of the gp120 surface envelope glycoprotein is an approximately 35-residue-long, frequently glycosylated, highly variable, disulfide-bonded structure that has a major influence on HIV-1 tropism. Thus the sequence of V3, directly or indirectly, can determine which coreceptor (CCR5 or CXCR4) is used to trigger the fusion potential of the Env complex, and hence which cells the virus can infect. V3 also influences HIV-1's sensitivity to, and ability to escape from, e...
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- Publication status:
- Published
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- Publisher copy:
- 10.1089/aid.2005.21.171
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Authors
Bibliographic Details
- Journal:
- AIDS research and human retroviruses
- Volume:
- 21
- Issue:
- 2
- Pages:
- 171-189
- Publication date:
- 2005-02-01
- DOI:
- EISSN:
-
1931-8405
- ISSN:
-
0889-2229
- Source identifiers:
-
23003
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:23003
- UUID:
-
uuid:5d45c6c7-fef2-4185-8899-85cb6e4d61e7
- Local pid:
- pubs:23003
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2005
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