- Abstract:
-
The third variable region, V3, of the gp120 surface envelope glycoprotein is an approximately 35-residue-long, frequently glycosylated, highly variable, disulfide-bonded structure that has a major influence on HIV-1 tropism. Thus the sequence of V3, directly or indirectly, can determine which coreceptor (CCR5 or CXCR4) is used to trigger the fusion potential of the Env complex, and hence which cells the virus can infect. V3 also influences HIV-1's sensitivity to, and ability to escape from, e...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1089/aid.2005.21.171
-
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- Journal:
- AIDS research and human retroviruses
- Volume:
- 21
- Issue:
- 2
- Pages:
- 171-189
- Publication date:
- 2005-02-05
- DOI:
- EISSN:
-
1931-8405
- ISSN:
-
0889-2229
- URN:
-
uuid:5d45c6c7-fef2-4185-8899-85cb6e4d61e7
- Source identifiers:
-
23003
- Local pid:
- pubs:23003
- Language:
- English
- Keywords:
- Copyright date:
- 2005
Journal article
V3: HIV's switch-hitter.
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