Journal article icon

Journal article

V3: HIV's switch-hitter.

Abstract:

The third variable region, V3, of the gp120 surface envelope glycoprotein is an approximately 35-residue-long, frequently glycosylated, highly variable, disulfide-bonded structure that has a major influence on HIV-1 tropism. Thus the sequence of V3, directly or indirectly, can determine which coreceptor (CCR5 or CXCR4) is used to trigger the fusion potential of the Env complex, and hence which cells the virus can infect. V3 also influences HIV-1's sensitivity to, and ability to escape from, e...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1089/aid.2005.21.171

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
AIDS research and human retroviruses
Volume:
21
Issue:
2
Pages:
171-189
Publication date:
2005-02-01
DOI:
EISSN:
1931-8405
ISSN:
0889-2229
Source identifiers:
23003
Language:
English
Keywords:
Pubs id:
pubs:23003
UUID:
uuid:5d45c6c7-fef2-4185-8899-85cb6e4d61e7
Local pid:
pubs:23003
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP