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Journal article

V3: HIV's switch-hitter.

Abstract:

The third variable region, V3, of the gp120 surface envelope glycoprotein is an approximately 35-residue-long, frequently glycosylated, highly variable, disulfide-bonded structure that has a major influence on HIV-1 tropism. Thus the sequence of V3, directly or indirectly, can determine which coreceptor (CCR5 or CXCR4) is used to trigger the fusion potential of the Env complex, and hence which cells the virus can infect. V3 also influences HIV-1's sensitivity to, and ability to escape from, e...

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Publication status:
Published

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Publisher copy:
10.1089/aid.2005.21.171

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
AIDS research and human retroviruses
Volume:
21
Issue:
2
Pages:
171-189
Publication date:
2005-02-05
DOI:
EISSN:
1931-8405
ISSN:
0889-2229
URN:
uuid:5d45c6c7-fef2-4185-8899-85cb6e4d61e7
Source identifiers:
23003
Local pid:
pubs:23003

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