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Complement receptors regulate differentiation of bone marrow plasma cell precursors expressing transcription factors Blimp-1 and XBP-1.

Abstract:

Humoral immune responses are thought to be enhanced by complement-mediated recruitment of the CD21-CD19-CD81 coreceptor complex into the B cell antigen receptor (BCR) complex, which lowers the threshold of B cell activation and increases the survival and proliferative capacity of responding B cells. To investigate the role of the CD21-CD35 complement receptors in the generation of B cell memory, we analyzed the response against viral particles derived from the bacteriophage Qbeta in mice defi...

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Publication status:
Published

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Publisher copy:
10.1084/jem.20042239

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Journal:
The Journal of experimental medicine
Volume:
201
Issue:
6
Pages:
993-1005
Publication date:
2005-03-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:5d42a88f-ea48-42bb-b411-c800d2c8fbc7
Source identifiers:
469734
Local pid:
pubs:469734

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