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Journal article

Mice exclusively expressing the short isoform of Smad2 develop normally and are viable and fertile.

Abstract:

Smad2 and Smad3 are closely related effectors of TGFbeta/Nodal/Activin-related signaling. Smad3 mutant mice develop normally, whereas Smad2 plays an essential role in patterning the embryonic axis and specification of definitive endoderm. Alternative splicing of Smad2 exon 3 gives rise to two distinct protein isoforms. The short Smad2(Deltaexon3) isoform, unlike full-length Smad2, Smad2(FL), retains DNA-binding activity. Here, we show that Smad2(FL) and Smad2(Deltaexon3) are coexpressed throu...

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Publication status:
Published

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Publisher copy:
10.1101/gad.1243205

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
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Journal:
Genes and development
Volume:
19
Issue:
1
Pages:
152-163
Publication date:
2005-01-05
DOI:
EISSN:
1549-5477
ISSN:
0890-9369
URN:
uuid:5d320e92-7201-4c37-bbda-83e990eeb78f
Source identifiers:
29093
Local pid:
pubs:29093

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